RT info:eu-repo/semantics/article
T1 Telocytes in neuromuscular spindles
A1 Díaz-Flores Varela, Lucio
A1 Gutiérrez, Ricardo
A1 Sáez, Francisco J.
A1 Madrid, Juan F.
A1 Díaz-Flores Jr., Lucio
K1 Telocytes
K1 muscle spindles
K1 stromal cells
K1 telopodes
K1 musculoaponeurotic fibromatosis
K1 inflammatory myopathy
AB A new cell type named telocyte (TC) has recently been identified in various stromal tissues, including skeletal muscle interstitium. The aim of this study was to investigate by means of light (conventional and immunohistochemical procedures) and electron microscopy the presence of TCs in adult human neuromuscular spindles (NMSs) and lay the foundations for future research on their behaviour during human foetal development and in skeletal muscle pathology. A large number of TCs were observed in NMSs and were characterized ultrastructurally by very long, initially thin, moniliform prolongations (telopodes - Tps), in which thin segments (podomeres) alternated with dilations (podoms). TCs formed the innermost and (partially) the outermost layers of the external NMS capsule and the entire NMS internal capsule. In the latter, the Tps were organized in a dense network, which surrounded intrafusal striated muscle cells, nerve fibres and vessels, suggesting a passive and active role in controlling NMS activity, including their participation in cell-to-cell signalling. Immunohistochemically, TCs expressed vimentin, CD34 and occasionally c-kit/CD117. In human foetus (22-23 weeks of gestational age), TCs and perineural cells formed a sheath, serving as an interconnection guide for the intrafusal structures. In pathological conditions, the number of CD34-positive TCs increased in residual NMSs between infiltrative musculoaponeurotic fibromatosis and varied in NMSs surrounded by lymphocytic infiltrate in inflammatory myopathy. We conclude that TCs are numerous in NMSs (where striated muscle cells, nerves and vessels converge), which provide an ideal microanatomic structure for TC study.
YR 2012
FD 2012
LK http://riull.ull.es/xmlui/handle/915/36266
UL http://riull.ull.es/xmlui/handle/915/36266
LA en
DS Repositorio institucional de la Universidad de La Laguna
RD 10-may-2024