RT info:eu-repo/semantics/article
T1 Cognitive decline is mediated by gray matter changes during middle age
A1 Díaz-Flores Varela, Lucio
A1 Ferreira, Daniel
A1 Molina, Yaiza
A1 Machado, Alejandra
A1 Westman, Eric
A1 Wahlund, Lars Olof
A1 Nieto, Antonieta
A1 Correia, Rut
A1 Junqué, Carme
A1 Barroso, José
K1 Cognitive decline
K1 Gray matter changes
K1 Middle age
AB The present theoretical framework of Alzheimer’s disease proposes that pathophysiological changesoccur 10e20 years before the diagnosis of dementia. We addressed the question of how age-relatedchanges in gray matter mediate the cognitive performance during middle age. Eighty-two participants(40e50 years,  2) were assessed with a comprehensive neuropsychological battery covering a broadspectrum of cognitive domains and components. Mediation effects were studied with hierarchicalregression and bootstrapping analysis. Results showed that more vulnerable cognitive components wererelated to executive functioning and in a lesser degree to processing speed. Age-related differences ingray matter mainly involved the frontal lobes. Moreover, age-related differences in visuoconstructive,visuospatial functions, reaction time, and mental flexibility and executive control were mediated byseveral gray matter regions. It is important to increase the knowledge of the impact of brain changes oncognitive function during middle age. To define the early stages of the aging process may allow earlydetection of pathologic changes and therapeutic interventions.
SN 0197-4580
YR 2014
FD 2014
LK http://riull.ull.es/xmlui/handle/915/36270
UL http://riull.ull.es/xmlui/handle/915/36270
LA en
DS Repositorio institucional de la Universidad de La Laguna
RD 17-jun-2024