RT info:eu-repo/semantics/article
T1 Differential expression profile of genes involved in the immune response associated to progression of chronic Chagas disease
A1 Carmelo, Emma
A1 Gómez, Inmaculada
A1 López, Manuel Carlos
A1 Carrilero, Bartolomé
A1 Benítez, Celia
A1 Simón, Marina
A1 Segovia, Manuel
A1 Thomas, M. Carmen
A2 Obstetricia y GinecologíaPediatría, Medicina Preventiva y Salud Pública, Toxicología y Medicina Legal y Forense y Parasitología
A2 Investigación en Parasitología
AB Amongthe neglected tropical diseases, Chagas disease is a major public health problem. The infection, caused by the parasite Trypanosoma cruzi, affects about 6–7 million people. The disease courses with an initial acute phase which, in the absence of treatment, becomes chronic. The chronic phase is initially asymptomatic, but in 40% of patients the disease progresses to clinical manifestations, being the most frequent and severe those affecting the cardiac system. The mechanisms underlying the development of cardiac disease are not yet fully understood, but this could depend on an unbalanced infection-triggered immune response. In this study, we have determined the expression level of 106 immune-related genes in patients in an early stage of cardiac disease (CCC I) and compared them with the expression present in asymptomatic patients (IND) as well as in healthy donors (HD). The results obtained have allowed us to identify a differential gene expression profile in chronic patients, as well as the identification of relevant immune pathways in which these genes participate. Therefore, our results contribute to the knowledge of the immunological mechanisms that are activated along chronic Chagas disease and, as a consequence, will help in the clinic management of the patients affected by this disease.
YR 2023
FD 2023
LK http://riull.ull.es/xmlui/handle/915/37282
UL http://riull.ull.es/xmlui/handle/915/37282
LA en
NO This work was supported by grant PID2019-109090RB-I00 /AEI/10.13039/ 501100011033 from the Programa Estatal I+D+I, Spanish Ministry of Science and Innovation (MICINN) to (MCT, MCL, IG); RICET, Network for Cooperative Research in Tropical Diseases and FEDER (RD16/0027/0005) to (MCL), RD16/0027/0001 to (EC) and RD16/0027/0016) to (MS)
DS Repositorio institucional de la Universidad de La Laguna
RD 22-nov-2024