RT info:eu-repo/semantics/article
T1 The sera from individuals suffering from cutaneous leishmaniasis due to Leishmania brazilensis present antibodies against parasitic conserved proteins, but not their human counterparts
A1 Carmelo, Emma
A1 Zurita, A.I.
A1 Martínez, E.
A1 Valladares Hernández, Basilio
A2 Obstetricia y GinecologíaPediatría, Medicina Preventiva y Salud Pública, Toxicología y Medicina Legal y Forense y Parasitología
A2 Investigación en Parasitología
K1 autoimmunity
K1 immune response
K1 histone
K1 chaperone
K1 Leishmania braziliensis
AB Sera from individuals suffering from leishmaniasis have been shown to strongly react against conserved proteins from the parasite, such as ribosomal, histones and heat-shock proteins. Some of these proteins have also been described as immunogenic in several auto-immune syndromes, and the detection of antibodies against them is considered to be indicative of disorder of the immune system. In this paper, we investigate whether there is any relationship between the recognition of some conserved proteins from Leishmania braziliensis by individuals suffering from cutaneous (CL) and mucocutaneous (MCL) leishmaniasis, and the recognition of the human homologues of these antigens found in sufferers from autoimmune diseases. Our findings reveal that the immune response generated during CL and MCL is elicited specifically by the parasitic histone H1 and Hsp70, since the CL and MCL sera do not react against their human counterparts. In addition, evidence is presented showing the specific recognition of human proteins by the autoimmune sera, showing only a weak crossreaction with the most divergent regions of the parasitic proteins.
YR 2006
FD 2006
LK http://riull.ull.es/xmlui/handle/915/37283
UL http://riull.ull.es/xmlui/handle/915/37283
LA en
NO Revista: ParasiteISSN: 1252-607XAño de publicación: 2006Volumen: 13Número: 3Páginas: 231-236Tipo: Artículo
DS Repositorio institucional de la Universidad de La Laguna
RD 21-dic-2024