RT info:eu-repo/semantics/article
T1 Fabrication of Zn-Sr-doped laser-spinning glass nanofibers with antibacterial properties
A1 Echezarreta López, María Magdalena
A1 Miguel, Trinidad de
A1 Quintero, Fé´lix
A1 Pou, Juan
A1 Landín, Mariana
A2 Ingeniería Química y Tecnología Farmacéutica
A2 Departamento de Farmacia y Tecnología Farmacéutica de la Facultad de Farmacia de la Universidad de Santiago de Compostela
Departamento de Microbiología y Parasitología de la Facultad de Farmacia de la Universidad de Santiago de Compostela
Applied Physics DepartmentEE Industrial, University of Vigo
K1 Bioactive glass
K1 laser-spinning
K1 doped nanofiber
K1 antibacterial property
K1 zinc
K1 strontium
AB The morphology and dimensions of bioactive materials are essential attributes to promote tissue culture. Bioactive materials with nanofibrous structure have excellent potential to be used as bone-defect fillers, since they mimic the collagen in the extracellular matrix. On the other hand, bioactive glasses with applications in regenerative medicine may present antibacterial properties, which depend on glass composition, concentration and the microorganisms tested. Likewise, their morphology may influence their antibacterial activity too. In the present work, the laser-spinning technique was used to produce bioactive glass nanofibers of two different compositions: 45S5 Bioglass and ICIE16M, bioactive glass doped with zinc and strontium. Their antibacterial activity against Staphylococcus aureus was tested by culturing them in dynamic conditions. Bacterial growth index profiles during the first days of experiment can be explained by the variations in the pHvalues of the media. The bactericidal effect of the doped nanofibers at longer times is justified by the release of zinc and strontium ions. Cytotoxicity was analyzed by means of cell viability tests performed with BALB/3T3 cell line.
YR 2016
FD 2016
LK http://riull.ull.es/xmlui/handle/915/37308
UL http://riull.ull.es/xmlui/handle/915/37308
LA en
NO Financiado por proyecto FEDER POCTEP 0330IBEROMARE1P (UE) y por Xunta de Galicia (CN2012/292)
DS Repositorio institucional de la Universidad de La Laguna
RD 22-nov-2024