RT info:eu-repo/semantics/article
T1 Utility of nuclear magnetic resonance spectroscopy to characterize the structure of dexamethasone sodium phosphate inclusion complexes with cyclodextrins in solution and to analyze potential competitive effects
A1 Echezarreta López, María Magdalena
A1 Perdomo López, I.
A1 Estrada, E.
A1 Vila-Jato, J.L.
A1 Torres-Labandeira, J.J.
A2 Ingeniería Química y Tecnología Farmacéutica
K1 glucocorticoids
K1 cyclodextrins
K1 ophthalmic solutions
K1 nuclear magnetic resonance spectroscopy
K1 molecular modeling
K1 micelles
AB The interaction between dexamethasone sodium phosphate (DSP) and four cyclodextrin (CyD) derivatives [2,6-di-O-b-cyclodextrin (DIMEB), g-cyclodextrin (g-CyD), and hydroxypropyl-b-cyclodextrin with either 2.7 or 4.6 degrees of substitution (HPbCyD 2.7 and HPbCyD 4.6, respectively)] was investigated by proton nuclear magnetic resonance spectroscopy (1H NMR). The data suggested the formation of inclusion complexes in solution in which B andC rings ofthe moleculeare located inside the cavity. Nevertheless, the structure, in terms of depth within CyD, depends on the derivative considered. Molecular mechanics calculations of DSPcomplexes withDIMEB and g-CyD support the NMR results. The potential displacement of DSP from the CyD cavity by usual ophthalmic drugs (e.g., polymyxin B, trimethoprim, and benzalkonium chloride) was determined by NMR. The technique has been found useful to analyze this problem in pharmaceutical preparations
YR 2002
FD 2002
LK http://riull.ull.es/xmlui/handle/915/37314
UL http://riull.ull.es/xmlui/handle/915/37314
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NO Financiado por Xunta de Galicia under project PGIDT99-PX120305
DS Repositorio institucional de la Universidad de La Laguna
RD 23-jun-2024