RT info:eu-repo/semantics/article
T1 Mineralized alginate hydrogels using marine carbonates for bone tissue engineering applications
A1 Echezarreta López, María Magdalena
A1 Díaz-Rodríguez, P.
A1 García-Triñanes, P.
A1 Santoveña Estévez, Ana María
A1 Landín, Mariana
A2 Ingeniería Química y Tecnología Farmacéutica
A2 Grupo de investigación: Desarrollo de medicamentos; 
Dpto. FarmacologíaFarmacia y Tecnología Farmacéutica, R+D Pharma Group (GI-1645),
Instituto de Bioingeniería en Red para el Envejecimiento Saludable-IBEROS Network
K1 Biominerals
K1 Mineralization
K1 Bone
K1 Hydrogel
K1 Marine carbonate particles
K1 Tissue engineering
AB The search for an ideal bone tissue replacement has led to the development of new composite materials designed to simulate the complex inorganic/organic structure of bone. The present work is focused on the development of mineralized calcium alginate hydrogels by the addition of marine derived calcium carbonate biomineral particles. Following a novel approach, we were able to obtain calcium carbonate particles of high purity and complex micro and nanostructure dependent on the source material. Three different types of alginates were selected to develop inorganic/organic scaffolds in order to correlate alginate composition with scaffold properties and cell behavior. The incorporation of calcium carbonates into alginate networks was able to promote extracellular matrix mineralization and osteoblastic differentiation of mesenchymal stem cells when added at 7mg/ml. We demonstrated that the selection of the alginate type and calcium carbonate origin is crucial to obtain adequate systems for bone tissue engineering as they modulate the mechanical properties and cell differentiation.
YR 2018
FD 2018
LK http://riull.ull.es/xmlui/handle/915/37321
UL http://riull.ull.es/xmlui/handle/915/37321
LA en
NO Proyecto financiado por: Interreg V-A POCTEP Program (0245_IBEROS_1_E) of EU (FEDER)
DS Repositorio institucional de la Universidad de La Laguna
RD 27-mar-2025