RT info:eu-repo/semantics/article
T1 Glibornuride-ß-cyclodextrin inclusion complexes: Preparation, structural characterization and in vitro dissolution behaviour
A1 Echezarreta López, María Magdalena
A1 Torres-Labandeira, Juan J.
A1 Santana-Penín, Lourdes
A1 Vila-Jato, José L.
A2 Ingeniería Química y Tecnología Farmacéutica
AB Phase·solubility studies of the complexation of glibornuride (GB) with α-, β- and γ-cydodextrin (CyD) showed that the most stable complex is formed with β-CyD. The effects of β-CyD on chemical shift values in 1H-NMR spectra of GB in aqueous médium suggest that it ís the bornyl part of the drug which is bound inside the CyD cavity. Solid inclusion complexes were obtained by coprecipitation and freeze-drying methods, and characterized by X-ray diffractometry and differential scanning calorimetry. Druq solubility was improved by inclusion in solid complexes obtained by either method
YR 1993
FD 1993
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DS Repositorio institucional de la Universidad de La Laguna
RD 23-jun-2024