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T1 Effect of water-soluble polymers on the aqueous solutility and complexing abilities of bropirimine with dimethyl-ß and hydroxypropyl-ß- cyclodextrin
A1 Echezarreta López, María Magdalena
A1 Torres-Labandeira, Juan J.
A1 Castineiras-Seijo, L.
A1 Vila-Jato, José L.
A2 Ingeniería Química y Tecnología Farmacéutica
AB Bropirímine (2-amino-5-bromo-6-phenyl-4(3 )-pyrimidinone,ABPP) is an orally active immunomodulator thatincreases endogenous alpha-interfcron and other cytokines.Its low aqueous solubilily determines a low oral bioavailability(1 ),Cyclodextrins CD are water-soluble, hydrophobic torus-shapcdcyclic oligosaccharides, that can accommodate intheir cavities water-insoluble drugs to form water-solubleinclusion complexes. Because of these properties CD havebeen used to enhance drug solubility, stability and bioavailabilíty(2-4). Hydroxypropyl β-cyclodextrin derivatives havebeen extensively used in pharmaceutical formulationowing 10 its high water solubilily (>50 % w/v) and low toxicity(5-6). Bcsides, methylated β-cyclodextrins show an improvementon water solubility of the natural parent and thccomplexation capability improves significantly (7).Polymers are know to interact with CDs and, it havebeen shown that at low concentrations, hydrophilic polymers,such as hydroxypropyl rnethylcellulose (HPMC),carboximethylcellulose sodium salt (CMC Na) or polyvinylpyrrolidone(PVP), increase the complexing abilitiesof CDs (8).The purpose of this study was to investígate thc effectof various water-soluble polymers on the cyclodextrincomplexation of bropirirnine. The efficiency of complexatíonwas evaluated by determining the solubilizing effectsof two cyclodextrin derivatives, dimethyl-β - andhydroxypropyl-β-cyclodextrin
YR 1999
FD 1999
LK http://riull.ull.es/xmlui/handle/915/37328
UL http://riull.ull.es/xmlui/handle/915/37328
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DS Repositorio institucional de la Universidad de La Laguna
RD 23-jun-2024