RT info:eu-repo/semantics/article
T1 Interaction of diclofenac sodium with and hydroxypropyl-ß-cyclodextrin in solution
A1 Echezarreta López, María Magdalena
A1 Pose-Vilarnovo, B.
A1 Santana-Penín, L.
A1 Pérez-Marcos, M.B.
A1 Vila-Jato, José L.
A1 Torres-Labandeira, J.J.
A2 Ingeniería Química y Tecnología Farmacéutica
K1 Diclofenac sodium
K1 β-cyclodextrin
K1 hydroxypropyl- β -cyclodextrin
K1 Nuclear magnetic resonance
K1 X-ray diffractometry
K1 Differential scanning calorimetry
K1 Dissolution properties
AB The formation of inclusion compounds of diclofenac sodium withβ- and hydroxypropyl- β -cyclodextrins was studied in solution byphase solubility techniques and by 1H-NMR spectroscopy. Phasesolubility diagrams revealed the formation of a 1/1 complex with both cyclodextrin derivatives in simulated gastric juice pH 1.2, with a similar stability constant, i.e. 100.6 M·' for β-cyclodextrin and 115.8 M·' for hydroxypropyl- β -cyclodextrin. The continuous variation method was utilized to elucidate the stoichiometry, determine the formation of complex with 1/1 and 1/2 drug/cyclodextrin ratio in deuterated water.Solid inclusion complexes were obtained by freeze-drying. X-ray diffractometry and differential scanning calorimetry showed differences between the complexes and their corresponding physical mixture and individual components. The solubility of diclofenac sodium increased significantly in the presence of cyclodextrins. Enhancement was better from the β-cyclodextrin systems
YR 1999
FD 1999
LK http://riull.ull.es/xmlui/handle/915/37330
UL http://riull.ull.es/xmlui/handle/915/37330
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DS Repositorio institucional de la Universidad de La Laguna
RD 23-jun-2024