RT info:eu-repo/semantics/article
T1 The Subcortical Default Mode Network and Alzheimer's Disease: A systematic review and Activation Likelihood Estimation Meta-Analysis.
A1 Acebes Vindel, Ángel José
A1 Seoane, Sara
A1 van den Heuvel, Martijn
A1 Janssen, Niels
A2 Ciencias Médicas Básicas
A2 Grupo de investigación: Mecanismos Moleculares en NeurodegeneraciónInstituto de tecnologías Biomédicas (ITB). Grupo propio de la Universidad de
La Laguna.
IP del grupo: Ángel Acebes
AB The default mode network is a central cortical brain network suggested to play a major role in several disorders and to be particularlyvulnerable to the neuropathological hallmarks of Alzheimer’s disease. Subcortical involvement in the default mode network and itsalteration in Alzheimer’s disease remains largely unknown. We performed a systematic review, meta-analysis and empirical validationof the subcortical default mode network in healthy adults, combined with a systematic review, meta-analysis and network analysis ofthe involvement of subcortical default mode areas in Alzheimer’s disease. Our results show that, besides the well-known cortical default mode network brain regions, the default mode network consistently includes subcortical regions, namely the thalamus, lobuleand vermis IX and right Crus I/II of the cerebellum and the amygdala. Network analysis also suggests the involvement of the caudatenucleus. In Alzheimer’s disease, we observed a left-lateralized cluster of decrease in functional connectivity which covered the medialtemporal lobe and amygdala and showed overlap with the default mode network in a portion covering parts of the left anterior hippocampus and left amygdala. We also found an increase in functional connectivity in the right anterior insula. These results confirm theconsistency of subcortical contributions to the default mode network in healthy adults and highlight the relevance of the subcorticaldefault mode network alteration in Alzheimer’s disease.
YR 2024
FD 2024
LK http://riull.ull.es/xmlui/handle/915/37381
UL http://riull.ull.es/xmlui/handle/915/37381
LA en
DS Repositorio institucional de la Universidad de La Laguna
RD 26-jun-2024