RT info:eu-repo/semantics/article
T1 Heterogeneous dopamine neurochemistry in the striatum: The fountain-drain matrix.
A1 Morales Pérez, Ingrid
A1 Rodríguez, Manuel
A1 Gómez, Isabel
A1 González, Sergio
A1 González Hernández, Tomás
A1 González Mora, José Luis
A2 Ciencias Médicas Básicas
A2 Grupo de Neurobiología y Neurología Experimental.
AB In contrast to the relatively high attention paid to the structural heterogeneity of striatal dopamine (DA) innervation, little attention has been focused on the possible striatal heterogeneity for release and uptake of DA. By using amperometric methods, we found striatal regions showing a DA decrease during the medial forebrain bundle stimulation (drain areas) near to other zones that showed an increase in DA concentration (fountain areas). Both areas were intermixed to form a tridimensional matrix to regulate DA concentration throughout the striatum (fountaindrain matrix). The response to electrical stimuli of different amplitudes and durations and to different drugs (-methyl-Ltyrosine, cocaine,-butyrolactone, and haloperidol) suggests that regional differences for both DA release/DA uptake and DA cell firing autoregulation are behind the striatal fountain-drain matrix. The high diversity of DA activity observed in the striatum is a new framework for analyzing experimental and clinical phenomena.
YR 2006
FD 2006
LK http://riull.ull.es/xmlui/handle/915/38558
UL http://riull.ull.es/xmlui/handle/915/38558
LA en
DS Repositorio institucional de la Universidad de La Laguna
RD 21-nov-2024