RT info:eu-repo/semantics/article
T1 The Functional Connectivity of Intralaminar Thalamic Nuclei in the Human Basal Ganglia
A1 Morales Pérez, Ingrid
A1 Rodríguez Sabaté, Clara
A1 Llanos, Catalina
A1 García Álvarez, Roberto
A1 Sabaté, Magdalena
A1 Rodríguez, Manuel
A2 Ciencias Médicas Básicas
A2 Grupo de Neurobiología y Neurología Experimental
K1 basal ganglia
K1 intralaminar thalamus
K1 functional connectivity
AB Projections of the centromedian-parafasicularis neurons of the intralaminar thalamus are major inputs of the striatum. Their functional role in the activity of human basal ganglia (BG) is not well known. The aim of this work was to study the functional connectivity of intralaminar thalamic nuclei with other BG by using the correlations of the BOLD signal recorded during “resting” and a motor task. Intralaminar nuclei showed a marked functional connectivity with all the tested BG, which was observed during “resting” and did not change with the motor task. As regards the intralaminar nuclei, BG connectivity was much lower for the medial dorsal nucleus (a thalamic nucleus bordering the intralaminar nuclei) and for the default mode network (although intralaminar nuclei showed a negative correlation with the default mode network). After the “regression” of intralaminar nuclei activity (partial correlation), the functional connectivity of the caudate and putamen nuclei with other BG decreased (but not with the primary sensorimotor cortex). Present data provide evidence that intralaminar nuclei are not only critical for striatal activity but also for the global performance of human BG, an action involving subcortical BG loops more than cortico-subcortical loops. The high correlation found between BG suggest that, similarly to that reported in other brain centers, the very-slow frequency fluctuations are relevant for the functional activity of these centers.
YR 2015
FD 2015
LK http://riull.ull.es/xmlui/handle/915/38560
UL http://riull.ull.es/xmlui/handle/915/38560
LA en
DS Repositorio institucional de la Universidad de La Laguna
RD 22-nov-2024