RT info:eu-repo/semantics/article
T1 The dynamic of basal ganglia activity with a multiple covariance method: influences of Parkinson's disease
A1 Morales Pérez, Ingrid
A1 Rodríguez Sabaté, Clara
A1 Puertas Avendaño, Ricardo
A1 Rodríguez, Manuel
A2 Ciencias Médicas Básicas
A2 Grupo de Neurobiología y Neurología Experimental
K1 basal ganglia
K1 motor cortex
K1 functional connectivity
K1 functional profile method
K1 Parkinson’s disease
AB The closed-loopcortico-subcortical pathways of basal gangliahavebeenextensivelyused todescribe thephysiologyof these centresandtojustifythefunctionaldisordersofbasalgangliadiseases.Thisapproachjustifiessomeexperimentalandclinicaldata butnotothers,andfurthermore, itdoesnot includeanumberofsubcorticalcircuitsthatmayproduceamorecomplexbasalgangliadynamicthanthatexpectedforclosed-looplinearnetworks.Thisworkstudiedthefunctionalconnectivityofthemainregions ofthebasalgangliamotorcircuitwithmagneticresonanceimagingandanewmethod(functionalprofilemethod),whichcananalyse themultiplecovariantactivityofhumanbasalganglia.The functionalprofilemethodidentifiedthemost frequent covariant functional status (profiles)of thebasal gangliamotorcircuit,orderingthemaccordingtotheir relative frequencyandidentifying themostfrequentsuccessionsbetweenprofiles(profiletransitions).Thefunctionalprofilemethodclassifiedprofilesasinputprofiles thataccept theinformationcomingfromothernetworks,outputprofiles involvedintheoutputofprocessedinformationtoother networksandhighlyinterconnectedinternalprofilesthataccept transitionsfrominputprofilesandsendtransitionstooutputprofiles.Profiletransitionsshowedapreviouslyunobservedfunctionaldynamicofhumanbasalganglia,suggestingthatthebasalgangliamotorcircuitmayworkasadynamicmultiplecovariancenetwork.Thenumberof internalprofilesandinternal transitions showedastrikingdecrease inpatientswithParkinson’sdisease, afactnotobservedfor inputandoutputprofiles.This suggests thatbasalgangliaofpatientswithParkinson’sdiseaserespondtorequirementscomingfromotherneuronalnetworks,butbecause the internal processingof information isdrasticallyweakened, its responsewill be insufficient andperhaps alsoself-defeating. Thesemarkedeffectswere foundinpatientswithfewmotordisorders, suggestingthat the functionalprofilemethodmaybean earlyproceduretodetectthefirststagesoftheParkinson’sdiseasewhenthemotordisordersarenotveryevident.Themultiplecovarianceactivityfoundpresentsacomplementarypointofviewtothecortico-subcorticalclosed-loopmodelofbasalganglia.The functionalprofilemethodmaybeeasilyappliedtootherbrainnetworks,anditmayprovideadditionalexplanationsfortheclinical manifestationsofotherbasalgangliadisorders.
YR 2020
FD 2020
LK http://riull.ull.es/xmlui/handle/915/38578
UL http://riull.ull.es/xmlui/handle/915/38578
LA en
DS Repositorio institucional de la Universidad de La Laguna
RD 19-oct-2024