RT info:eu-repo/semantics/article
T1 Striatal interaction among dopamine, glutamate and ascorbate.
A1 Morales Pérez, Ingrid
A1 Fuentes, Ángel
A1 Ballaz, Santiago
A1 Obeso, José A.
A1 Rodríguez, Manuel
A2 Ciencias Médicas Básicas
A2 Grupo de Neurobiología y Neurología Experimental
K1 Glutamate
K1 Dopamine
K1 Ascorbic acid
K1 Striatum
K1 Parkinson’s disease
AB Despite evidence suggesting the interaction among glutamate (GLU), dopamine (DA) and ascorbic acid (AA) in the striatum, their actions are often studied separately. Microdialysis was used here to quantify the extracellular interaction among GLUeDAeAA in the striatum of rats, an interaction which was compared with those studied in the substantia nigra (SN). Perfusion of GLU by reverse microdialysis increased DA and decreased 3,4-dihydroxyphenylacetic acid (DOPAC) in the extracellular medium of the striatum, but increased both DA and DOPAC in the SN. The increase of extracellular DA-concentration induced by the local DA-perfusion decreased the extracellular level of GLU and glutamine, an effect that, as suggested by the GLU and glutamine increase observed after the haloperidol administration, probably involves the D2 dopamine receptor. Local administration of AA increased the extracellular DA, decreased DOPAC and had no effect on GLU and glutamine. Present data suggest that, in the striatum, GLU-release inhibits DA-uptake, DA-release inhibits GLU-release, and AA-release prevents DA-oxidation increasing its extracellular diffusion. These effects were different in the SN where GLU probably promoted the DA-release instead of inhibiting the DA-uptake as presumably occurred in the striatum. Present data denote a marked GLUeDAeAA interaction in the striatum, which might be relevant for the pharmacological control of basal ganglia disorders.
YR 2012
FD 2012
LK http://riull.ull.es/xmlui/handle/915/38582
UL http://riull.ull.es/xmlui/handle/915/38582
LA en
DS Repositorio institucional de la Universidad de La Laguna
RD 27-sep-2024