RT info:eu-repo/semantics/article
T1 Self-induced accumulation of glutamate in striatal astrocytes and basal ganglia excitotoxicity.
A1 Morales Pérez, Ingrid
A1 Rodríguez, Manuel
A2 Ciencias Médicas Básicas
A2 Grupo de Neurobiología y Neurología Experimental
K1 glutamate
K1 astrocyte
K1 striatum
K1 excitotoxicity
AB Excitotoxicity induced by high levels of extracellular glutamate (GLU) has been proposed as a cause of cell degeneration in basal ganglia disorders. This phenomenon is normally prevented by the astrocytic GLU-uptake and the GLU-catabolization to less dangerous molecules. However, high-GLU can induce reactive gliosis which could change the neuroprotective role of astrocytes. The striatal astrocyte response to high GLU was studied here in an in vivo rat preparation. The transient striatal perfusion of GLU (1 h) by reverse microdialysis induced complex reactive gliosis which persisted for weeks and which was different for radial-like glia, protoplasmic astrocytes and fibrous astrocytes. This gliosis was accompanied by a persistent cytosolic accumulation of GLU (immunofluorescence quantif ied by confocal microscope), which persisted for weeks (self-induced glutamate accumulation), and which was associated to a selective decrease of glutamine synthetase activity. This massive and persistent self-induced glutamate accumulation in striatal astrocytes could be an additional factor for the GLU-induced excitotoxicity, which has been implicated in the progression of different basal ganglia disorders.
YR 2012
FD 2012
LK http://riull.ull.es/xmlui/handle/915/38584
UL http://riull.ull.es/xmlui/handle/915/38584
LA en
DS Repositorio institucional de la Universidad de La Laguna
RD 25-nov-2024