RT info:eu-repo/semantics/article
T1 The Influence of Aging on the Functional Connectivity of the Human Basal Ganglia.
A1 Morales Pérez, Ingrid
A1 Rodríguez Sabaté, Clara
A1 Rodríguez, Manuel
A2 Ciencias Médicas Básicas
A2 Grupo de Neurobiología y Neurología Experimental
K1 aging
K1 basal ganglia
K1 functional connectivity
K1 hand motion
K1 resting state
AB Although basal ganglia (BG) are involved in the motor disorders of aged people, the effect of aging on the functional interaction of BG is not well-known. This work was aimed at studying the influence of aging on the functional connectivity of the motor circuit of BG (BGmC).Thirty healthy volunteers werestudied (young-group 26.4±5.7yearsold;agedgroup 63.1 ± 5.8 years old) with a procedure planned to prevent the spurious functional connectivity induced by the closed-loop arrangement of the BGmC. BG showed different functional interactions during the inter-task intervals and when subjects did not perform any voluntary task. Aging induced marked changes in the functional connectivity of the BGmC during these inter-task intervals. The finger movements changed the functional connectivity of the BG, these modifications were also different in the aged-group. Taken together, these data show a marked effect of aging on the functional connectivity of the BGmC, and these effects may be at the basis of the motor handicaps of aged people during the execution of motor-tasks and when they are not performing any voluntary motor task.
YR 2022
FD 2022
LK http://riull.ull.es/xmlui/handle/915/38589
UL http://riull.ull.es/xmlui/handle/915/38589
LA en
DS Repositorio institucional de la Universidad de La Laguna
RD 27-sep-2024