RT info:eu-repo/semantics/article
T1 The functional connectivity in the motor loop of human basal ganglia
A1 Morales Pérez, Ingrid
A1 Rodríguez Sabaté, Clara
A1 Sabaté, Magdalena
A1 Llanos, Catalina
A1 Sánchez, Alberto
A1 Rodríguez, Manuel
A2 Ciencias Médicas Básicas
A2 Grupo de Neurobiología y Neurología Experimental
K1 Cerebralcortex
K1 Basalganglia
K1 Functional connectivity
K1 Resting state
K1 Handmotion
AB Basal ganglia interact in a complex way which is still not completely understood. The model generally used to explain basal ganglia interactions is based on experimental data in animals, but its validation in humans has been hampered by methodological restrictions. The time-relationship (partial correlation) of the fluctuations of the blood-oxygenlevel-dependent signals recorded in the main basal ganglia was used here (32 healthy volunteers; 18–72 years of age; 16 males and 16 females) to test whether the interaction of the main basal ganglia in humans follows the pattern of functional connectivity in animals. Data showed that most basal ganglia have a functional connectivity which is compatible with that of the established closed-loop model. The strength of the connectivity of some basal ganglia changed with finger motion, suggesting that the functional interactions between basal ganglia are quickly restructured by the motor tasks. The present study with the motor cortico-BG loop centers supports the circling dynamic of the basal ganglia model in humans, showing that motor tasks may change the functional connectivity of these centers.
YR 2016
FD 2016
LK http://riull.ull.es/xmlui/handle/915/38590
UL http://riull.ull.es/xmlui/handle/915/38590
LA en
DS Repositorio institucional de la Universidad de La Laguna
RD 22-dic-2024