RT info:eu-repo/semantics/article
T1 Parkinson's disease as a result of aging
A1 Morales Pérez, Ingrid
A1 Rodríguez, Manuel
A1 Rodríguez Sabaté, Clara
A1 Sánchez, Alberto
A1 Sabaté, Magdalena
A2 Ciencias Médicas Básicas
A2 Grupo de Neurobiología y Neurología Experimental
K1 aging
K1 dopamine
K1 nigrostriatal neurons
K1 neurodegeneration
K1 Parkinson’s disease
AB It is generally considered that Parkinson’s disease is induced by specific agents that degenerate a clearly defined population of dopaminergic neurons. Data commented in this review suggest that this assumption is not as clear as is often thought and that aging may be critical for Parkinson’s disease. Neurons degenerating in Parkinson’s disease also degenerate in normal aging, and the different agents involved in the etiology of this illness are also involved in aging. Senescence is a wider phenomenon affecting cells all over the body, whereas Parkinson’s disease seems to be restricted to certain brain centers and cell populations. However, reviewed data suggest that Parkinson’s disease may be a local expression of aging on cell populations which, by their characteristics (high number of synaptic terminals and mitochondria, unmyelinated axons, etc.), are highly vulnerable to the agents promoting aging. The development of new knowledge about Parkinson’s disease could be accelerated if the research on aging and Parkinson’s disease were planned together, and the perspective provided by gerontology gains relevance in this field.
YR 2015
FD 2015
LK http://riull.ull.es/xmlui/handle/915/38595
UL http://riull.ull.es/xmlui/handle/915/38595
LA en
DS Repositorio institucional de la Universidad de La Laguna
RD 22-nov-2024