RT info:eu-repo/semantics/article
T1 The role of non-synaptic extracellular glutamate
A1 Morales Pérez, Ingrid
A1 Rodríguez, Manuel
A1 Sabaté, Magdalena
A1 Rodríguez Sabaté, Clara
A2 Ciencias Médicas Básicas
A2 Grupo de Neurobiología y Neurología Experimental
K1 Glutamate
K1 Astrocyte
K1 Extracellular extrasynaptic space
AB Although there are some mechanisms which allow the direct crossing of substances between the cytoplasm of adjacent cells (gap junctions), most substances use the extracellular space to diffuse between brain cells. The present work reviews the behavior and functions of extracellular glutamate (GLU). There are two extracellular pools of glutamate (GLU) in the brain, a synaptic pool whose functions in the excitatory neurotransmission has been widely studied and an extrasynaptic GLU pool although less known nonetheless is gaining attention among a growing number of researchers. Evidence accumulated over the last years shows a number of mechanisms capable of releasing glial GLU to the extracellular medium, thus modulating neurons, microglia and oligodendrocytes, and regulating the immune response, cerebral blood flow, neuronal synchronization and other brain functions. This new scenario is expanding present knowledge regarding the role of GLU in the brain under different physiological and pathological conditions.
YR 2013
FD 2013
LK http://riull.ull.es/xmlui/handle/915/38597
UL http://riull.ull.es/xmlui/handle/915/38597
LA en
DS Repositorio institucional de la Universidad de La Laguna
RD 25-nov-2024