RT info:eu-repo/semantics/article
T1 Differential expression of liver and kidney proteins in a mouse model for primary hyperoxaluria type I.
A1 Hernández Fernaud, Juan Ramón
A1 Salido, Eduardo C.
A2 BioquímicaMicrobiología, Biología Celular y Genética
A2 Max Planck Institute for BiochemistryDepartment of Proteomics and Signal Transduction.
AB Mutations in the alanine-glyoxylate aminotransferase gene (AGXT) are responsible for primary hyperoxaluria type I, a rare disease characterized by excessive hepatic oxalate production that leads to renal failure. A deeper understanding of the changes in the metabolic pathways secondary to the lack of AGXT expression is needed in order to explore substrate depletion as a therapeutic strategy to limit oxalate production in primary hyperoxaluria type I. We have developed an Agxt knockout (AgxtKO) mouse that reproduces some key features of primary hyperoxaluria type I. To improve our understanding of the metabolic adjustments subsequent to AGXT deficiency, we performed a proteomic analysis of the changes in expression levels of various subcellular fractions of liver and kidney metabolism linked to the lack of AGXT. In this article, we report specific changes in the liver and kidney proteome of AgxtKO mice that point to significant variations in gluconeogenesis, glycolysis and fatty acid pathways.
YR 2010
FD 2010
LK http://riull.ull.es/xmlui/handle/915/38818
UL http://riull.ull.es/xmlui/handle/915/38818
LA en
DS Repositorio institucional de la Universidad de La Laguna
RD 14-ene-2025