RT info:eu-repo/semantics/article
T1 Quantitative mass spectrometry-based proteomics in angiogenesis.
A1 Hernández Fernaud, Juan Ramón
A1 Reid, Steven E.
A1 Neilson, Lisa J.
A1 Zanivan, Sara
A2 BioquímicaMicrobiología, Biología Celular y Genética
A2 The Beatson Institute for Cancer ResearchGlasgow, UK
AB Theprocessofnewbloodvesselformationfrompre-existingonesiscalledangiogenesis.Beyond playing a critical role in the physiological development of the vascular system, angiogenesis is a well-recognised hallmark of cancer. Unbiased system-wide approaches are required to complement the current knowledge, and intimately understand the molecular mechanisms regulating this process in physiological and pathological conditions. In this review we describe the cellular and molecular dynamics regulating the physiological growth of vessels and their deregulation in cancer, survey in vitro and in vivo models currently exploited to investigate various aspects of angiogenesis and describe state-of-the-art and most widespread methods andtechnologies in MSshotgunproteomics. Finally, we focus on current applications of MS to better understand endothelial cell behaviour and propose how modern proteomics can impact on angiogenesis research.
YR 2013
FD 2013
LK http://riull.ull.es/xmlui/handle/915/38825
UL http://riull.ull.es/xmlui/handle/915/38825
LA en
DS Repositorio institucional de la Universidad de La Laguna
RD 22-dic-2024