RT info:eu-repo/semantics/article
T1 High blood pressure effects on the blood to cerebrospinal fluid barrier and cerebrospinal fluid protein composition: a two-dimensional electrophoresis study in spontaneously hypertensive rats.
A1 Hernández Fernaud, Juan Ramón
A1 González Marrero, Ibrahim
A1 Castañeyra Ruiz, Leandro
A1 González Toledo, Juan M.
A1 Castañeyra Ruiz, Agustín
A1 Paz Carmona, Héctor de
A1 Castro Fuentes, Rafael
A1 Castañeyra Perdomo, Agustín
A1 Carmona Calero, Emilia María
A2 BioquímicaMicrobiología, Biología Celular y Genética
A2 Servicio de Proteómica. Universidad de La Laguna.
AB The aim of the present work is to analyze the cerebrospinal fluid proteomic profile, trying to find possible biomarkers of the effects of hypertension of the blood to CSF barrier disruption in the brain and their participation in the cholesterol and β-amyloid metabolism and inflammatory processes. Cerebrospinal fluid (CSF) is a system linked to the brain and its composition can be altered not only by encephalic disorder, but also by systemic diseases such as arterial hypertension, which produces alterations in the choroid plexus and cerebrospinal fluid protein composition. 2D gel electrophoresis in cerebrospinal fluid extracted from the cistern magna before sacrifice of hypertensive and control rats was performed. The results showed different proteomic profiles between SHR and WKY, that α-1-antitrypsin, apolipoprotein A1, albumin, immunoglobulin G, vitamin D binding protein, haptoglobin and α-1-macroglobulin were found to be up-regulated in SHR, and apolipoprotein E, transthyretin, α-2-HS-glycoprotein, transferrin, α-1β-glycoprotein, kininogen and carbonic anhidrase II were down-regulated in SHR. The conclusion made here is that hypertension in SHR produces important variations in cerebrospinal fluid proteins that could be due to a choroid plexus dysfunction and this fact supports the close connection between hypertension and blood to cerebrospinal fluid barrier disruption.
YR 2013
FD 2013
LK http://riull.ull.es/xmlui/handle/915/38828
UL http://riull.ull.es/xmlui/handle/915/38828
LA en
DS Repositorio institucional de la Universidad de La Laguna
RD 22-nov-2024