RT info:eu-repo/semantics/article
T1 Voltage-dependent anion channel as a resident protein of lipid rafts: post-transductional regulation by estrogens and involvement in neuronal preservation against Alzheimer's disease.
A1 Hernández Fernaud, Juan Ramón
A1 Herrera, José Luis
A1 Díaz, Mario
A1 Salido, Eduardo
A1 Alonso, Rafael
A1 Fernández, Cecilia
A1 Morales, Araceli
A1 Marín, Raquel
A2 BioquímicaMicrobiología, Biología Celular y Genética
A2 Servicio de Proteómica. Universidad de La Laguna.
K1 Alzheimer’s disease
K1 amyloid beta
K1 estrogen neuroprotection
K1 estrogen receptor
K1 voltage-dependent anion channel.
AB The voltage-dependent anion channel, VDAC, is present at the neuronal membrane, where it appears to participate, among others, in the extrinsic apoptotic pathway and in the modulation of amyloid-beta induced injury, suggesting the involvement of this channel in Alzheimer's disease (AD) neurotoxicity. VDAC is also highly concentrated in neuronal lipid raft microdomains of different mouse and human cognitive areas, where it has been shown associated with estrogen receptor alpha (ERα), as a part of a `signalosome' that may activate some intracellular signal transduction. At the plasma membrane level, estrogens and antiestrogens (tamoxifen) have been demonstrated to exert rapid antagonist effects on the activation of VDAC, through their distinct effects on the channel post-transductional modulation. Therefore, part of the alternative mechanisms of estrogen related to neuroprotection against amyloid-beta may involve VDAC phosphorylation, in order to maintain the channel in an unactivated (closing) state. Interestingly, VDAC-ERα association has been shown to be disrupted in neuronal lipid rafts of AD brains, in correlation with the aberrant lipid composition observed in these microstructures, suggesting that disturbance of protein interactions may be related to variation in the physico-chemical properties of these microdomains.
YR 2011
FD 2011
LK http://riull.ull.es/xmlui/handle/915/38830
UL http://riull.ull.es/xmlui/handle/915/38830
LA en
DS Repositorio institucional de la Universidad de La Laguna
RD 24-nov-2024