RT info:eu-repo/semantics/article
T1 Integrating pressure sensor control into semi-solid extrusion 3D printing to optimize medicine manufacturing
A1 Díaz-Torres, E.
A1 Rodríguez-Pombo, L.
A1 Ong, Jun Jie
A1 Basit, Abdul W.
A1 Santoveña Estévez, Ana María
A1 Fariña, José B.
A1 Alvarez-Lorenzo, Carmen
A1 Goyanes, Alvaro
A2 Ingeniería Química y Tecnología Farmacéutica
A2 Grupo de invetsigación: Desarrollo galénico de medicamentos
K1 Ink characterization
K1 Rheology
K1 Printing formulations and drug products
K1 Process analytical technology (PAT)
K1 Paediatric formulations
K1 Direct ink writing of medicines
K1 3D printed pharmaceuticals and drug delivery systems
AB Semi-solid extrusion (SSE) is a three-dimensional printing (3DP) process that involves the extrusion of a gel or paste-like material via a syringe-based printhead to create the desired object. In pharmaceuticals, SSE 3DP has already been used to manufacture formulations for human clinical studies. To further support its clinical adoption, the use of a pressure sensor may provide information on the printability of the feedstock material in situ and under the exact printing conditions for quality control purposes. This study aimed to integrate a pressure sensor in an SSE pharmaceutical 3D printer for both material characterization and as a process analytical technology (PAT) to monitor the printing process. In this study, three materials of different consistency were tested (soft vaseline, gel-like mass and paste-like mass) under 12 different conditions, by changing flow rate, temperature, or nozzle diameter. The use of a pressure sensor allowed, for the first time, the characterization of rheological properties of the inks, which exhibited temperature-dependent, plastic and viscoelastic behaviours. Controlling critical material attributes and 3D printing process parameters may allow a quality by design (QbD) approach to facilitate a high-fidelity 3D printing process critical for the future of personalized medicine.
SN 2590-1567
YR 2022
FD 2022
LK http://riull.ull.es/xmlui/handle/915/39006
UL http://riull.ull.es/xmlui/handle/915/39006
LA Español
DS Repositorio institucional de la Universidad de La Laguna
RD 03-ene-2025