RT nfo:eu-repo/semantics/article
T1 Clozapine-associated pericarditis and pancreatitis in children and adolescents: A systematic literature review and pharmacovigilance study using the VigiBase database.
A1 Cuevas Castresana, Carlos De Las
A1 De Filippis, Renato
A1 Sanz Álvarez, Emilio José
A1 Schoretsanitis, Georgios
A1 Correll, Christoph U.
A1 De León, José
A2 Medicina InternaDermatología y Psiquiatría
K1 Clozapine/administration and dosage
K1 Clozapine/adverse effects
K1 Clozapine/toxicity
K1 Pancreatitis
K1 Pericardial effusion
K1 Pericarditis
AB Background: The literature has paid very little attention to pericarditis, pericardial effusion and pancreatitis during clozapine treatment in children and adolescents. Methods: Cases of clozapine-associated pericarditis and pancreatitis in children were studied using searches in: 1) PubMed (June 16, 2023), and 2) the World Health Organization’s pharmacovigilance database (June 1, 2022), VigiBase. VigiBase uses a logarithmic measure of disproportionality called the information component (IC). Results: The PubMed search yielded 3 clozapine-associated pericarditis cases, 1  ancreatitis case and 1 with both.VigiBase provided a significant clozapine-associated pericarditis IC = 3.6 with an IC025 = 2.9 (only 3 cases were expected while 22 were observed). VigiBase provided a significant clozapine-associated pancreatitis IC = 2.2 with an IC025 = 1.4 (only 3 cases were expected while 16 were observed). In VigiBase clozapine-associated pericarditis and pericardial effusion in youth looked similar and on a continuum with myocarditis, as myocarditis, pericarditis and pancreatitis appeared to occur mainly during clozapine titration. Combining PubMed and VigiBase we identified: 1) 29 cases of at least possible clozapine-associated pericarditis/pericardial effusion (6 probable and 23 possible) including 7 cases with and 22 without myocarditis, and 2) 17 cases of clozapineassociated pancreatitis (1 definite and 16 possible). Two of the pancreatitis cases occurred during overdoses.No fatal outcomes were found in any clozapine-associated pericarditis and pancreatitis cases.Conclusions: Despite the lack of attention in the literature to clozapine-associated pericarditis and pancreatitis, results demonstrate that they can happen in youth, particularly during titration. Pericarditis and pancreatitis appear to be forms of clozapine-associated inflammation during dose titration.
SN 1573-2509
YR 2024
FD 2024
LK http://riull.ull.es/xmlui/handle/915/39627
UL http://riull.ull.es/xmlui/handle/915/39627
LA en
DS Repositorio institucional de la Universidad de La Laguna
RD 24-nov-2024