RT info:eu-repo/semantics/article
T1 Peripheral vascular disease and kidney transplant outcomes: Rethinking an important ongoing complication
A1 Hernández Marrero, Domingo Jerónimo
A1 Vázquez, Teresa
A1 Armas Padrón, Ana María
A1 Alonso Titos, Juana
A1 Casas, Cristina
A1 Gutiérrez, Elena
A1 Jironda, Cristina
A1 Cabello, Mercedes
A1 López, Verónica
A2 Medicina InternaDermatología y Psiquiatría
K1 Peripheral vascular disease
K1 Kidney transplant
AB Peripheral vascular disease (PVD) is highly prevalent in patients on the waiting list for kidney transplantation (KT) and after transplantation and is associated with impaired transplant outcomes. Multiple traditional and nontraditional risk factors, as well as uremia- and transplant-related factors, affect 2 processes that can coexist, atherosclerosis and arteriosclerosis, leading to PVD. Some pathogenic mechanisms, such as inflammation-related endothelial dysfunction, mineral metabolism disorders, lipid alterations, or diabetic status, may contribute to the development and progression of PVD. Early detection of PVD before and after KT, better understanding of the mechanisms of vascular damage, and application of suitable therapeutic approaches could all minimize the impact of PVD on transplant outcomes. This review focuses on the following issues: (1) definition, epidemiological data, diagnosis, risk factors, and pathogenic mechanisms in KT candidates and recipients; (2) adverse clinical consequences and outcomes; and (3) classical and new therapeutic approaches.
SN 1534-6080
YR 2021
FD 2021
LK http://riull.ull.es/xmlui/handle/915/39728
UL http://riull.ull.es/xmlui/handle/915/39728
LA en
DS Repositorio institucional de la Universidad de La Laguna
RD 13-nov-2025