RT info:eu-repo/semantics/article
T1 A Voxel-Based Morphometric Study of Gray Matter in Specific Phobia.
A1 Marrero Quevedo, Rosario Josefa
A1 Yolanda Álvarez-Pérez
A1 Olivares Pérez, Teresa
A1 Rivero Pérez, Francisco Luis
A1 Peñate Castro, Wenceslao
A1 Bethencourt Pérez, Juan Manuel
A1 Fumero Hernández, Ascensión Ángeles
A2 Psicología ClínicaPsicobiología y Metodología
A2 IUNE
K1 MRI
K1 prefrontal areas
K1 putamen
K1 gray matter volume
K1 specific phobia
AB The objective of this study was to analyze the neurostructural abnormalities of brain areasresponsible for the acquisition and maintenance of fear in small animal phobia by comparing graymatter volume (GMV) in individuals with phobia and non-fearful controls. Structural magneticresonance imaging was obtained from 62 adults (79% female) assigned to one of two groups: 31 werediagnosed with small animal phobia and 31 were non-fearful controls. To investigate structuralalterations, a whole-brain voxel-based morphometry analysis was conducted to compare the GMV ofthe brain areas involved in fear between both groups. The results indicated that individuals witha small animal specific phobia showed smaller GMV in cortical regions, such as the orbitofrontal(OFC) and medial frontal cortex, and greater GMV in the putamen than non-fearful controls. Thesebrain areas are responsible for avoidant behavior (putamen) and emotional regulation processes orinhibitory control (prefrontal cortex (PFC)), which might suggest a greater vulnerability of phobicindividuals to acquiring non-adaptive conditioned responses and emotional dysregulation. Thefindings provide preliminary support for the involvement of structural deficits in OFC and medialfrontal cortex in phobia, contributing to clarify the neurobiological substrates for phobias.
YR 2023
FD 2023
LK http://riull.ull.es/xmlui/handle/915/39767
UL http://riull.ull.es/xmlui/handle/915/39767
LA Inglés
DS Repositorio institucional de la Universidad de La Laguna
RD 21-nov-2024