RT info:eu-repo/semantics/article
T1 AmotL2, IQGAP1, and FKBP51 Scaffold Proteins in Glioblastoma Stem Cell Niches
A1 Morales González, Manuel José
A1 Rotoli, Deborah
A1 Díaz-Flores, Lucio
A1 Gutiérrez, Ricardo
A1 Ávila, Julio
A1 Martín-Vasallo, Pablo
A2 Medicina InternaDermatología y Psiquiatría
K1 AmotL2
K1 IQGAP1
K1 FKBP51
K1 angiogenesis
K1 glioblastoma stem cells
K1 scaffold proteins
K1 stem cell niche
K1 stemness
K1 tumor heterogeneity
K1 tumor immune infiltrate
K1 tumor microenvironment
AB Glioma stem cells (GSCs) live in a continuous process of stemness reprogramming to achieve specific cell commitmentwithin the so-called GSC niches, specifically located in periarteriolar regions. In this review, we analyze the expressionlevels, cellular and subcellular location, and role of three scaffold proteins (IQGAP1, FKBP51, and AmotL2) in GSC niches.Scaffold proteins contribute to cell differentiation, migration, and angiogenesis in glioblastoma. It could be of diagnosticinterest for establishing stages, for therapeutic targets, and for improving glioblastoma prognosis, which is still at theexperimental level. (J Histochem Cytochem 70:9–16, 2022)
YR 2022
FD 2022
LK http://riull.ull.es/xmlui/handle/915/40024
UL http://riull.ull.es/xmlui/handle/915/40024
LA en
DS Repositorio institucional de la Universidad de La Laguna
RD 16-may-2025