RT info:eu-repo/semantics/article
T1 IQGAP1, AmotL2, and FKBP51 Scaffoldins in the Glioblastoma Microenvironment
A1 Morales González, Manuel José
A1 Rotoli, Deborah
A1 Maeso, María-del-C.
A1 Ávila, Julio
A1 Pérez-Rodríguez, Natalia D.
A1 Mobasheri, Ali
A1 Noorden, Cornelis J. F. van
A2 Medicina InternaDermatología y Psiquiatría
K1 AmotL2
K1 astrocytoma cells
K1 FKBP51
K1 glioblastoma microenvironment
K1 glioma stem cells
K1 IQGAP1
K1 pericytes
K1 scaffold proteins
K1 tumor-associated macrophages (TAMs)
AB Glioblastoma (GB) is the most frequently occurring and aggressive primary brain tumor. Glioma stem cells (GSCs) andastrocytoma cells are the predominant malignant cells occurring in GB besides a highly heterogeneous population ofmigrating, neovascularizing and infiltrating myeloid cells that forms a complex tumor microenvironment (TME). Crosstalk between the TME cells is pivotal in the biology of this tumor and, consequently, adaptor proteins at critical junctionsof signaling pathways may be crucial. Scaffold proteins (scaffolins or scaffoldins) integrate external and internal stimulito regulate various signaling pathways, interacting simultaneously with multiple proteins involved. We investigatedby double and triple immunofluorescence the localization of IQGAP1, AmotL2, and FKBP51, three closely relatedscaffoldins, in malignant cells and TME of human GB tumors. We found that IQGAP1 is preferentially expressed inastrocytoma cells, AmotL2 in GSCs, and FKBP51 in white blood cells in human GB tumors. As GSCs are specially the targetfor novel therapies, we will investigate in further studies whether AmotL2 inhibition is effective in the treatment of GB.(J Histochem Cytochem 67:481–494, 2019)
YR 2019
FD 2019
LK http://riull.ull.es/xmlui/handle/915/40035
UL http://riull.ull.es/xmlui/handle/915/40035
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DS Repositorio institucional de la Universidad de La Laguna
RD 28-nov-2024