RT info:eu-repo/semantics/article
T1 Na, K-ATPase isoenzyme son colorectal cancer and liver metastases
A1 Morales González, Manuel José
A1 Baker Bechmann, Marc
A1 Rotoli, Deborah
A1 Maeso, María del Carmen
A1 García, María del Pino
A1 Ávila, Julio
A1 Mobasheri, Ali
A1 Martín-Vasallo, Pablo
A2 Medicina InternaDermatología y Psiquiatría
K1 Na/K-ATPase isozymes
K1 sodium pump isozymes
K1 colorectal cancer
K1 colorectal cancer liver metastases
K1 Na/K-ATPase isoforms colorectal cancer immunohistochemistry
AB The goal of this study was to define Na,K-ATPase α and β subunit isoform expression andisozyme composition in colorectal cancer cells and liver metastases. The α1, α3, and β1isoforms were the most highly expressed in tumor cells and metastases; in the plasmamembrane of non-neoplastic cells and mainly in a cytoplasmic location in tumor cells.α1β1 and α3β1 isozymes found in tumor and metastatic cells exhibit the highest andlowest Na+ affinity respectively and the highest K+ affinity. Mesenchymal cell isozymespossess an intermediate Na+ affinity and a low K+ affinity. In cancer, these ions arelikely to favor optimal conditions for the function of nuclear enzymes involved in mitosis,especially a high intra-nuclear K+ concentration. A major and striking finding of this studywas that in liver, metastasized CRC cells express the α3β1 isozyme. Thus, the α3β1isozyme could potentially serve as a novel exploratory biomarker of CRC metastatic cellsin liver.
YR 2016
FD 2016
LK http://riull.ull.es/xmlui/handle/915/40048
UL http://riull.ull.es/xmlui/handle/915/40048
LA en
DS Repositorio institucional de la Universidad de La Laguna
RD 27-abr-2025