RT info:eu-repo/semantics/article
T1 Changes in AmotL2 Expression in Cells of the Human Enteral Nervous System in Oxaliplatin-Induced Enteric Neuropathy.
A1 Morales González, Manuel José
A1 González-Fernández, Rebeca
A1 Martín-Ramírez, Rita
A1 Maeso, María del Carmen
A1 Lázaro, Alberto
A1 Ávila, Julio
A1 Martín-Vasallo, Pablo
A2 Medicina InternaDermatología y Psiquiatría
K1 AmotL2
K1 Enteral nervous system
K1 Oxaliplatin toxicity
K1 Gastrointestinal chemotherapy toxicity
K1 Enteral nervous system toxicity
AB Gastrointestinal (GI) toxicity is a common side effect in patients undergoing oxaliplatin (OxPt)-based chemotherapy for colorectal cancer (CRC). Frequently, this complication persists in the long term and could affect the efficacy of the treatment and the patient’s life quality. This long-term GI toxicity is thought to be related to OxPt-induced enteral neuropathy. AmotL2 is a member of the Angiomotin family of proteins, which play a role in cell survival, neurite outgrowth, synaptic maturation, oxidative stress protection, and inflammation. In order to assess the role of AmotL2 in OxPt-induced enteral neuropathy, we studied the expression of AmotL2 in cells of the enteric nervous system (ENS) of untreated and OxPt-treated CRC patients and its relationship with inflammation, using immunofluorescence confocal microscopy. Our results in human samples show that the total number of neurons and glial cells decreased in OxPt-treated patients, and TNF-α and AmotL2 expression was increased and colocalized in both neurons and glia. AmotL2 differential expression between OxPt-treated and untreated CRC patients shows the involvement of this scaffold protein in the inflammatory component and toxicity by OxPt in the ENS.
SN 2227-9059
YR 2024
FD 2024
LK http://riull.ull.es/xmlui/handle/915/40070
UL http://riull.ull.es/xmlui/handle/915/40070
LA en
DS Repositorio institucional de la Universidad de La Laguna
RD 18-nov-2025