RT info:eu-repo/semantics/article
T1 Circulating miR-206 and miR-1246 as Markers in the Early Diagnosis of Lung Cancer in Patients with Chronic Obstructive Pulmonary Disease
A1 Oliva Martín, Alexis Manuel
A1 Córdoba Lanús, Aída Elizabeth
A1 Domínguez de Barros, Angélica
A1 Mayato, Delia
A1 Gonzalvo, Francisca
A1 Remírez-Sanz, Ana
A1 Zulueta, Javier J.
A1 Celli, Bartolomé
A1 Casanova, Ciro
A2 Ingeniería Química y Tecnología Farmacéutica
A2 Instituto de Enfermedades Tropicales y Salud Pública de Canarias
K1 lung cancer
K1 COPD
K1 circulating miRNAs
K1 biomarkers
AB Lung cancer (LC) is the most common cause of cancer death, with 75% of cases being diagnosed in late stages. This study aimed to determine potential miRNAs as biomarkers for the early detection of LC in chronic obstructive pulmonary disease (COPD) cases. Ninety-nine patients were included, with registered clinical and lung function parameters followed for 6 years. miRNAs were determined in 16 serum samples from COPD patients (four with LC and four controls) by next generation sequencing (NGS) at LC diagnosis and 3 years before. The validation by qPCR was performed in 33 COPD-LC patients and 66 controls at the two time points. Over 170 miRNAs (≥10 TPM) were identified; among these, miR-224-5p, miR-206, miR-194-5p, and miR-1246 were significantly dysregulated (p < 0.001) in COPD-LC 3 years before LC diagnosis when compared to the controls. The validation showed that miR-1246 and miR-206 were differentially expressed in COPDpatients who developed LC three years before (p = 0.035 and p = 0.028, respectively). The in silico enrichment analysis showed miR-1246 and miR-206 to be linked to gene mediators in various signaling pathways related to cancer. Our study demonstrated that miR-1246 and miR-206 have potential value as non-invasive biomarkers of early LC detection in COPD patients who could benefit from screening programs.
YR 2023
FD 2023
LK http://riull.ull.es/xmlui/handle/915/40116
UL http://riull.ull.es/xmlui/handle/915/40116
LA en
DS Repositorio institucional de la Universidad de La Laguna
RD 31-dic-2024