RT info:eu-repo/semantics/article
T1 Improved short term outcomes of kidney transplants in controlled donation after the circulatory determination of death with the use of normothermic regional perfusion
A1 Hernández Marrero, Domingo Jerónimo
A1 Padilla, María
A1 Coll, Elizabeth
A1 Fernández-Pérez, Crisitina
A1 Pont, Teresa
A1 Ruiz, Ángel
A1 Pérez-Redondo, Marina
A1 Oliver, Eva
A1 Atutxa, Lander
A1 Manciño, José M.
A1 Daga, Domingo
A1 Miñambres, Eduardo
A1 Moya, José
A1 Vidal, Bárbara
A1 Dueñas- Jurado, José M.
A1 Mosteiro, Fernando
A1 Rodríguez-Salgado, Alberto
A1 Fernández-García, Esperanza
A1 Lara, Ramón
A1 Estébanez, Belén
A1 Rodríguez-Ferrero, María Luisa
A1 Barber, María
A1 García-López, Fernando
A1 Andrés, Amado
A1 Santiago, Carlos
A1 Zapatero, Ana
A1 Badenes, Rafael
A1 Carrizosa, Francisco
A1 Blanco, José J.
A1 Bernal, José L.
A1 Elola, Francisco J.
A1 Vidal, Crisitina
A1 Terrón, Christel
A1 Castro, Pablo
A1 Comas, Jordi
A1 Domínguez-Gil, Beatriz
A2 Medicina InternaDermatología y Psiquiatría
K1 Clinical research/practice
K1 Delayed graft function (DGF)
K1 Donors and donation
K1 Donation after circulatory death (DCD)
K1 Graft survivalkidney transplantation / nephrology
K1 Organ perfusion and preservation
K1 Organ procurement and allocation
AB Normothermic regional perfusion (NRP) allows the in situ perfusion of organs with oxygenated blood in donation after the circulatory determination of death (DCDD). We aimed at evaluating the impact of NRP on the short-term outcomes of kidney transplants in controlled DCDD (cDCDD). This is a multicenter, nationwide, retrospective study comparing cDCDD kidneys obtained with NRP versus the standard rapid recovery (RR) technique. During 2012–2018, 2302 cDCDD adult kidney transplants were performed in Spain using NRP (n = 865) or RR (n = 1437). The study groups differed in donor and recipient age, warm, and cold ischemic time and use of ex situ machine perfusion. Transplants in the NRP group were more frequently performed in high-volume centers (≥90 transplants/year). Through matching by propensity score, two cohorts with a total of 770 patients were obtained. After the matching, no statistically significant differences were observed between the groups in terms of primary nonfunction (p =.261) and mortality at 1 year (p =.111). However, the RR of kidneys was associated with a significantly increased odds of delayed graft function (OR 1.97 [95% CI 1.43–2.72]; p <.001) and 1-year graft loss (OR 1.77 [95% CI 1.01–3.17]; p =.034). In conclusion, compared with RR, NRP appears to improve the short-term outcomes of cDCDD kidney transplants.
SN 1600-6143
YR 2021
FD 2021
LK http://riull.ull.es/xmlui/handle/915/40234
UL http://riull.ull.es/xmlui/handle/915/40234
LA en
DS Repositorio institucional de la Universidad de La Laguna
RD 10-abr-2025