RT info:eu-repo/semantics/article
T1 Time dependent changes of klotho and FGF-23 levels after kidney transplantation: role of cold ischemia time, renal function and graft inflammation
A1 Hernández Marrero, Domingo Jerónimo
A1 Vázquez Sánchez, Teresa
A1 Sánchez Niño, María Dolores
A1 Ruíz Esteban, Pedro
A1 López, Verónica
A1 León, Myriam
A1 Caballero, Abelardo
A1 Ruíz Escalera, Juan Francisco
A1 Ortiz, Alberto
A1 Torres, Armando
A1 Rodríguez, Mariano
A2 Medicina InternaDermatología y Psiquiatría
K1 kidney transplant
K1 serum klotho levels
K1 serum FGF-23 levels
K1 graft function
K1 graft subclinical inflammation
K1 cold ischemia time
AB We investigated the evolution of serum klotho (s-Kl) and FGF-23 during the first two years post-kidney transplantation (KT), considering the cold ischemia time (CIT), glomerular filtration rate (GFR) and graft subclinical inflammation (SCI). We undertook a prospective, cohort, multicenter study of consecutive patients between April 2018 and January 2021 (with follow-up at 24 months). Subgroups were analyzed according to the median CIT (<14 vs. ≥14 h), the median GFR (≤40 vs. >40 mL/min/1.73 m2) and the presence of SCI at month 3. A total of 147 patients were included. s-Kl and fibroblast growth factor-23 (FGF-23) levels were measured at baseline and at months 3, 12 and 24. Graft biopsies (n = 96) were performed at month 3. All patients had low s-Kl levels at month 3. Patients with CIT < 14 h exhibited a significant increase in s-Kl at month 24. In patients with CIT ≥ 14 h, s-Kl at month 3 fell and lower s-Kl levels were seen at month 24. Patients with a GFR > 40 had a lesser decrease in s-Kl at month 3. FGF-23 fell significantly at months 3 and 12 in both GFR groups, a reduction maintained during follow-up. There were significant inter-group differences in s-Kl from months 3 to 24. CIT, GFR at 3 months and SCI were significantly associated with s-KI at month 3. A reduction in s-Kl at month 3 post-KT could be explained by longer CIT and delayed graft function as well as by impaired graft function. Early SCI may regulate s-Kl increase post-KT.
YR 2023
FD 2023
LK http://riull.ull.es/xmlui/handle/915/40238
UL http://riull.ull.es/xmlui/handle/915/40238
LA en
DS Repositorio institucional de la Universidad de La Laguna
RD 22-dic-2024