RT info:eu-repo/semantics/article
T1 Cognitive flexibility impairment in temporal lobe epilepsy: The impact of epileptic foci lateralization on executive functions
A1 Alonso Rodríguez, María Ángeles
A1 Cairós González, Mariana
A1 Verche,  Emilio
A1 Hernández Expósito, Sergio
A2 Psicología CognitivaSocial y Organizacional
A2 Grupo interuniversitario de investigaciones cognitivas - Universidad de La Laguna Instituto Universitario de Neurociencia- Universidad de La Laguna (IUNE)
K1 Epilepsy
K1 Temporal lobe epilepsy
K1 Executive functions
K1 Neuropsychological assessment
K1 Hemispheric lateralization
K1 Neuropsychology of Epilepsy
K1 Cognitive flexibility
AB Introduction: Temporal Lobe Epilepsy (TLE) has been associated with memory impairments, which are typically linked to hippocampal and mesial temporal cortex lesions. Considering the presence of extensive bidirectional frontotemporal connections, it can be hypothesized that executive dysfunction in TLE is modulated by the lateralization of the epileptic foci. Material and Methods: A comprehensive neuropsychological executive functions protocol was administered to 63 participants, including 42 individuals with temporal lobe epilepsy (20 with right-TLE and 22 with left-TLE) and 21 healthy controls aged 20–49. Results: The results indicate that TLE patients exhibit poorer executive performance compared to healthy controls in working memory (F(2,60) = 4.18, p <.01), planning (F(2,60) = 4.71, p <.05), set shifting (F(2,60) = 10.1, p <.001), phonetic verbal fluency (F(2,60) = 11.71, p <.01) and semantic verbal fluency (F(2,60) = 9.61, p <.001. No significant differences were found in cognitive inhibition. Furthermore, right-TLE patients showed lower performance than left-TLE in set shifting (F(1,61) = 6.45, p <.05), while no significant differences were observed in working memory, planning, inhibition, and verbal fluency. Conclusions: This research emphasize the importance of considering the lateralization of the temporal lobe focus to achieve a more accurate neuropsychological characterization. The cognitive differences between left and right TLE patients highlight the need for individualized approaches in their treatment and care.
SN 1525-5050
YR 2024
FD 2024
LK http://riull.ull.es/xmlui/handle/915/40248
UL http://riull.ull.es/xmlui/handle/915/40248
LA en
DS Repositorio institucional de la Universidad de La Laguna
RD 29-dic-2024