RT info:eu-repo/semantics/article
T1 A micro-extrusion 3D printing platform for fabrication of orodispersible printlets for pediatric use
A1 Santoveña Estévez, Ana María
A1 Díaz Torres, Eduardo
A1 Fariña Espinosa, José Bruno Celso
A2 Ingeniería Química y Tecnología Farmacéutica
A2 Desarrollo galénico de medicamentos
K1 Semi-solid micro-extrusion
K1 3D printing
K1 Pediatric drug delivery
K1 Quality by design (QbD)
K1 3D printer parametrization
K1 Hydrochlorothiazide orodispersible tablet
K1 Process Analytical Technology (PAT)
AB 3D printed pharmaceuticals offers the potential to manufacture personalized medicines for patients. Such technology is of particular benefit to pediatric populations from the offer of increased patient compliance and dose flexibility. With a bench-to-patient approach, this study established and optimized the critical parameters of the semi-solid micro-extrusion 3D printing process to guarantee the quality attributes of the final dosage form. Pediatrics orodispersible printlets of hydrochlorothiazide were manufactured through the modification of printing parameters, as well as printing surfaces materials. The printlets were characterized and the dimensions were measured using a digital caliper and computer vision algorithm. This study identified that the printing surface material and the first printing layer are critical parameters for high-resolution printlets. Following the optimization of 3D printing parameters, high quality orodispersible printlets loaded with hydrochlorothiazide – specifically tailored for pediatric patient’s dosage forms – were obtained (4.62 mm × 1.90 mm). Mass and content uniformity assays demonstrated that the printlets satisfied the requirements for orodispersible printlets set by the European Pharmacopoeia. As such, in order to transition from laboratory research towards the treatment of patients, distinguishing accurate 3D printing parameters is necessary for the manufacture of medicines with key quality attributes that follow Pharmacopoeia requirements.
YR 2021
FD 2021
LK http://riull.ull.es/xmlui/handle/915/40695
UL http://riull.ull.es/xmlui/handle/915/40695
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NO Este documento ya solicité que se incluyera en el respositorio junto con otros cuatro en octubre del año 2024, pero los demás si aparecen y éste no
DS Repositorio institucional de la Universidad de La Laguna
RD 25-abr-2025