RT info:eu-repo/semantics/article
T1 Telocytes in the Normal and Pathological Peripheral Nervous System
A1 Díaz-Flores Varela, Lucio
A1 Gutiérrez García, Ricardo
A1 Mª Pino García
A1 Sara Gayoso
A1 Emma Gutiérrez
A1 Carrasco Juan, José Luis
A2 Medicina Física y Farmacología
K1 telocytes
K1 nerves
K1 Meissner corpuscles
K1 appendicular neurogenic hyperplasia
K1 gallbladder neurogenic hyperplasia
K1 peripheral nervous system tumours
AB We studied telocytes/CD34+ stromal cells in the normal and pathological peripheralnervous system (PNS), for which we reviewed the literature and contributed our observationsunder light and electron microscopy in this field. We consider the following aspects: (A) generalcharacteristics of telocytes and the terminology used for these cells (e.g., endoneurial stromal cells)in PNS; (B) the presence, characteristics and arrangement of telocytes in the normal PNS, including(i) nerve epi-perineurium and endoneurium (e.g., telopodes extending into the endoneurial space);(ii) sensory nerve endings (e.g., Meissner and Pacinian corpuscles, and neuromuscular spindles);(iii) ganglia; and (iv) the intestinal autonomic nervous system; (C) the telocytes in the pathologic PNS,encompassing (i) hyperplastic neurogenic processes (neurogenic hyperplasia of the appendix andgallbladder), highly demonstrative of telocyte characteristics and relations, (ii) PNS tumours, such asneurofibroma, schwannoma, granular cell tumour and nerve sheath myxoma, and interstitial cell ofCajal-related gastrointestinal stromal tumour (GIST), (iii) tumour-invaded nerves and (iv) traumatic,metabolic, degenerative or genetic neuropathies, in which there are fewer studies on telocytes, e.g.,neuroinflammation and nerves in undescended testicles (cryptorchidism), Klinefelter syndrome,crush injury, mucopolysaccharidosis II (Hunter’s syndrome) and Charcot–Marie–Tooth disease
YR 2020
FD 2020
LK http://riull.ull.es/xmlui/handle/915/40823
UL http://riull.ull.es/xmlui/handle/915/40823
LA Inglés
DS Repositorio institucional de la Universidad de La Laguna
RD 22-may-2025