RT info:eu-repo/semantics/article
T1 Telomere shortening and accelerated aging in COPD: findings from the BODE cohort
A1 Cazorla Rivero, Sara Estefanía
A1 Espinoza Jiménez, Adriana
A1 Torres, Juan P. de
A1 Pajares, María J.
A1 Aguirre Jaime, Armando
A1 Celli, Bartolomé
A1 Casanova, Ciro
A1 Córdoba Lanús, Aída Elizabeth
A2 Medicina InternaDermatología y Psiquiatría
K1 COPD
K1 Telomeres
K1 Aging
AB Background: Chronic Obstructive Pulmonary Disease (COPD) may be associated with accelerated aging. Telomere shortening is a biomarker of aging. Cross-sectional studies describe shorter telomeres in COPD compared with matched controls. No studies have described telomere length trajectory and its relationship with COPD progression.We investigated telomere shortening over time and its relationship to clinical and lung function parameters in a COPD cohort and smoker controls without COPD.Methods: At baseline leukocyte telomere length was measured by qPCR in 121 smokers with COPD and 121 without COPD matched by age (T/S0). The measurements were repeated in 70 of those patients with COPD and 73 non-COPDsmokers after 3 years of follow up (T/S3).Results: At initial measurement, telomeres were shorter in COPD patients when compared to smoker controls (T/S = 0. 68 ± 0.25 vs. 0.88 ± 0.52, p = 0.003) independent from age and sex. During the follow-up period, we observed an accelerated telomere shortening in individuals with COPD in contrast to smoker controls (T/S0 = 0.66 ± 0.21 vs.T/S3 = 0.46 ± 0.16, p < 0.001, for the patients with COPD and T/S0 = 0.83 ± 0.56 vs. T/S3 = 0.74 ± 0.52, p = 0.023 for controls; GLIM, p = 0.001). This shortening was inversely related to the baseline telomere length (r = −0.49, p < 0.001). No significant relationship was found between the rate of change in telomere length and change in lung function in the patients with COPD (p > 0.05).Conclusions: Compared with smokers, patients with COPD have accelerated telomere shortening and this rate of attrition depends on baseline telomere length. Furthermore, the telomere length and its rate of shortening did not relate to clinical and lung function parameters changes over 3 years of follow-up.
SN 1465-993X
YR 2017
FD 2017
LK http://riull.ull.es/xmlui/handle/915/40844
UL http://riull.ull.es/xmlui/handle/915/40844
LA en
DS Repositorio institucional de la Universidad de La Laguna
RD 13-nov-2025