RT info:eu-repo/semantics/article
T1 Diuretic activity of some Smilax canariensis fractions
A1 Dévora Gutiérrez, Sandra
A1 Abdala Kuri, Susana
A1 Martín Herrera, Domingo
A1 Benjumea, D
A2 Medicina Física y Farmacología
K1 Smilax canariensis
K1 Diuretic activity
K1 Medicinal plant
K1 Urinary excretion
K1 Folk medicine
AB Ethnopharmacological relevance: Smilax canariensis is an endemic species of the Canary Islands, popularlyknown as “Zarzaparrilla sin espinas”. The rhizome, leaves and stem of this species has wide use in folkmedicine practice on the islands, where they are habitually employed as diuretic.Aim of the study: In this paper we report on the diuretic activity in experimental animals of severalfractions of the methanol extract of this species.Materials and methods: Four fractions of the methanol extract of the rhizomes, leaves and stem of Smilaxcanariensis (50 and 100 mg/kg), Furosemide and Hydrochlorotiazide (10 mg/kg), were orally administered to laboratory animals to evaluate their diuretic activity. Water excretion rate, pH, conductivity, andcontent of Na+, K+ and Cl− were measured in the urine of saline-loaded mice.Results: All the studied extracts showed an interesting increase of the diuresis, although the n-buthanol(27%; p < 0.05) and ethyl acetate extract (35%; p < 0.01), at 100 mg/kg p.o., showed the most interestingdiuretic activity, which suggested that this diuretic effect is associated with the compounds contained inthe fractions ofintermediate polarity (ethyl acetate and n-butanol), decreasing in themost extreme apolarand polar sub-extracts (dichloromethane and methanol: water respectively). The increase in diuresisproduced by these two extracts was very close to the values of Hydrochlorothiazide (32%) or Furosemide(39%), used as reference diuretics.Conclusions: These data, together with previous results on the aqueous and methanol extracts, reaffirmassertions made regarding the effectiveness of the extracts of this plant against urinary pathologies inthe Canary Islands folk medicine
YR 2012
FD 2012
LK http://riull.ull.es/xmlui/handle/915/40871
UL http://riull.ull.es/xmlui/handle/915/40871
LA en
DS Repositorio institucional de la Universidad de La Laguna
RD 24-abr-2025