RT info:eu-repo/semantics/article
T1 ent-Rosane and abietane diterpenoids as cancer chemopreventive agents
A1 Pérez Reyes, Carolina
A1 Núñez, Marvin J.
A1 Jiménez, Ignacio A.
A1 Hayashi, Hirotaka
A1 Tokuda, Harukuni
A1 Bazzocchi, Isabel L.
A2 BioquímicaMicrobiología, Biología Celular y Genética
A2 Instituto Universitario de Bio-Orgánica `Antonio GonzálezUnversidad de La Laguna
AB Two ent-rosane- (cuzcol, 1 and 6-dehydroxycuzcol, 2) and a abietatriene- (salvadoriol, 3) type diterpenoids have been isolated from Maytenus cuzcoina and Crossopetalum uragoga, respectively, along with five known diterpene compounds (4–8). Their stereostructures have been elucidated on the basis of spectroscopic analysis, including 1D and 2D NMR techniques, and computational data. The absolute configuration of cuzcol was determined by application of Riguera ester procedure. This is the first instance of isolation of ent-rosane diterpenoids from species of the Celastraceae. The isolated diterpenes were found to be potent anti-tumour-promoter agents, and carnosol (7) also showed a remarkable chemopreventive effect in an in vivo two-stage carcinogenesis model.
YR 2011
FD 2011
LK http://riull.ull.es/xmlui/handle/915/41118
UL http://riull.ull.es/xmlui/handle/915/41118
LA en
DS Repositorio institucional de la Universidad de La Laguna
RD 14-jun-2025