Metamizole or dipyrone is a drug that has been on the market for almost 100
years and is used for successful analgesic and antipyretic treatment.
Agranulocytosis is a very serious complication that can appear in patients after
the administration of metamizole, during or after treatment.
There is a great geographic variability in the incidence of agranulocytosis, being
higher in some northern European countries if we compare it with southern and
South American countries. The fact that more has been diagnosed in these
patients has suggested a predisposing hereditary factor, which is why some
studies go in this direction.
For this reason, there are many countries where its use is prohibited, others
where it is dispensed with a prescription and others where the sale is free.
