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HIV-1 Env associates with HLA-C free-chains at the cell membrane modulating viral infectivity.
dc.contributor.author | Valenzuela Fernández, Agustín | |
dc.contributor.author | Serena, Michela | |
dc.contributor.author | Parolini, Francesca | |
dc.contributor.author | Biswas, Priscilla | |
dc.contributor.author | Sironi, Francesca | |
dc.contributor.author | Blanco Miranda, Almudena | |
dc.contributor.author | Zoratti, Elisa | |
dc.contributor.author | Scupoli, Maria Teresa | |
dc.contributor.author | Ziglio, Serena | |
dc.contributor.author | Gibellini, Davide | |
dc.contributor.author | Romanelli, Maria Grazia | |
dc.contributor.author | Siccardi, Antonio | |
dc.contributor.author | Malnati, Mauro | |
dc.contributor.author | Beretta, Alberto | |
dc.contributor.author | Zipeto, Donato | |
dc.contributor.other | Medicina Física y Farmacología | |
dc.contributor.other | Grupo "Inmunología Celular y Viral" | |
dc.date.accessioned | 2024-01-15T21:09:34Z | |
dc.date.available | 2024-01-15T21:09:34Z | |
dc.date.issued | 2016 | |
dc.identifier.uri | http://riull.ull.es/xmlui/handle/915/35363 | |
dc.description.abstract | HLA-C has been demonstrated to associate with HIV-1 envelope glycoprotein (Env). Virions lacking HLA-C have reduced infectivity and increased susceptibility to neutralizing antibodies. Like all others MHC-I molecules, HLA-C requires β2-microglobulin (β2m) for appropriate folding and expression on the cell membrane but this association is weaker, thus generating HLA-C free-chains on the cell surface. In this study, we deepen the understanding of HLA-C and Env association by showing that HIV-1 specifically increases the amount of HLA-C free chains, not bound to β2m, on the membrane of infected cells. The association between Env and HLA-C takes place at the cell membrane requiring β2m to occur. We report that the enhanced infectivity conferred to HIV-1 by HLA-C specifically involves HLA-C free chain molecules that have been correctly assembled with β2m. HIV-1 Env-pseudotyped viruses produced in the absence of β2m are less infectious than those produced in the presence of β2m. We hypothesize that the conformation and surface expression of HLA-C molecules could be a discriminant for the association with Env. Binding stability to β2m may confer to HLA-C the ability to preferentially act either as a conventional immune-competent molecule or as an accessory molecule involved in HIV-1 infectivity. | en |
dc.format.mimetype | application/pdf | |
dc.language.iso | en | |
dc.relation.ispartofseries | Scientific Reports, 7:40037 | |
dc.rights | Licencia Creative Commons (Reconocimiento-No comercial-Sin obras derivadas 4.0 Internacional) | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es_ES | |
dc.title | HIV-1 Env associates with HLA-C free-chains at the cell membrane modulating viral infectivity. | en |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | 10.1038/srep40037 |