RT info:eu-repo/semantics/article
T1 Pramipexole restores depressed transmission in the ventral hippocampus following MPTP-lesion
A1 Castro Hernández, Javier
A1 Adlard, Paul A.
A1 Finkelstein, David I.
AB The hippocampus has a significant association with memory, cognition and emotions. The dopaminergic projections from both the ventral tegmental area and substantia nigra are thought to be involved in hippocampal activity. To date, however, few studies have investigated dopaminergicinnervation in the hippocampus or the functional consequences of reduced dopamine in disease models. Further complicating this, the hippocampus exhibits anatomical and functional differentiation along its dorso-ventral axis. In this work we investigated the role of dopamine on hippocampal long term potentiation using D-amphetamine, which stimulates dopamine release, and also examined how a dopaminergic lesion affects the synaptic transmission across the anatomic subdivisions of thehippocampus. Our findings indicate that a 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine induced dopaminergic lesion has time-dependent effects and impacts mainly on the ventral region of the hippocampus, consistent with the density of dopaminergic innervation. Treatment with a preferentialD3 receptor agonist pramipexole partly restored normal synaptic transmission and Long-Term Potentiation. These data suggest a new mechanism to explain some of the actions of pramipexole in Parkinson´s disease
LK http://riull.ull.es/xmlui/handle/915/14098
UL http://riull.ull.es/xmlui/handle/915/14098
DS Repositorio institucional de la Universidad de La Laguna
RD 30-abr-2024