RT info:eu-repo/semantics/article
T1 Disproportion in pericyte/endothelial cell proliferation and mechanisms of intussusceptive angiogenesis participate in bizarre vessel formation in glioblastoma
A1 González Gómez, Miriam
A1 Díaz Flores, Lucio
A1 Gutiérrez, Ricardo
A1 García, María del Pino
A1 Díaz-Flores, Lucio Jr
A1 González-Marrero, Ibrahim
A1 Ávila, Julio
A1 Martín Vasallo, Pablo
K1 glioblastoma
K1 pericytes
K1 endothelial cells
K1 intussusceptive angiogenesis
K1 bizarre/aberrant microvasculature
K1 glomeruloid bodies
K1 proliferation index
AB : Glioblastoma (GBM) is the most malignant tumor in the brain. In addition to the vascularpattern with thin-walled vessels and findings of sprouting angiogenesis, GBM presents a bizarremicrovasculature (BM) formed by vascular clusters, vascular garlands, and glomeruloid bodies.The mechanisms in BM morphogenesis are not well known. Our objective was to assess the roleof pericyte/endothelial proliferation and intussusceptive angiogenic mechanisms in the formationof the BM. For this purpose, we studied specimens of 66 GBM cases using immunochemistry andconfocal microscopy. In the BM, the results showed (a) transitional forms between the BM patterns,mostly with prominent pericytes covering all the abluminal endothelial cell (EC) surface of thevessels, (b) a proliferation index high in the prominent pericytes and low in ECs (47.85 times higher inpericytes than in ECs), (c) intravascular pillars (hallmark of intussusceptive angiogenesis) formed bytranscapillary interendothelial bridges, endothelial contacts of opposite vessel walls, and vessel loops,and (d) the persistence of these findings in complex glomeruloid bodies. In conclusion, disproportionin pericyte/EC proliferation and mechanisms of intussusceptive angiogenesis participate in BM formation. The contributions have morphogenic and clinical interest since pericytes and intussusceptiveangiogenesis can condition antiangiogenic therapy in GBM.
SN 2073-4409
YR 2021
FD 2021
LK http://riull.ull.es/xmlui/handle/915/35014
UL http://riull.ull.es/xmlui/handle/915/35014
LA en
DS Repositorio institucional de la Universidad de La Laguna
RD 12-jun-2024