RT info:eu-repo/semantics/article
T1 Intussusceptive angiogenesis and peg-socket junctions between endothelial cells and smooth muscle cells in early arterial intimal thickening
A1 González Gómez, Miriam
A1 Díaz Flores , Lucio
A1 Gutiérrez, Ricardo
A1 García,  Mª Pino
A1 Gayoso, Sara
A1 Carrasco, José Luis
A1 Díaz Flores, Lucio Jr.
A1 González Gómez,  Miriam
A1 Madrid,  Juan Francisco
K1 Arterial intimal thickening
K1 Angiogenesis
K1 Intussusceptive angiogenesis
K1 Peg-and-socket junctions
K1 Vascular regression
K1 Endothelial cells
K1 Vascular smooth muscle cells
K1 Platelets
AB Angiogenesis in arterial intimal thickening (AIT) has been considered mainly in late AIT stages and only refers to sprouting angiogenesis. We assess angiogenesis during early AIT development and the occurrence of the intussusceptive type. For this purpose, we studied AIT development in (a) human arteries with vasculitis in gallbladders with acute cholecystitis and urgent (n = 25) or delayed (n = 20) cholecystectomy, using immunohistochemical techniques and (b) experimentally occluded arterial segments (n = 56), using semithin and ultrathin sections and electron microscopy. The results showed transitory angiogenic phenomena, with formation of an important microvasculature, followed by vessel regression. In addition to the sequential description of angiogenic and regressive findings, we mainly contribute (a) formation of intravascular pillars (hallmarks of intussusception) during angiogenesis and vessel regression and (b) morphological interrelation between endothelial cells (ECs) in the arterial wall and vascular smooth muscle cells (VSMCs), which adopt a pericytic arrangement and establish peg-and-socket junctions with ECs. In conclusion, angiogenesis and vessel regression play an important role in AIT development in the conditions studied, with participation of intussusceptive angiogenesis during the formation and regression of a provisional microvasculature and with morphologic  interrelation between ECs and VSMCs.
YR 2020
FD 2020
LK http://riull.ull.es/xmlui/handle/915/35027
UL http://riull.ull.es/xmlui/handle/915/35027
LA 
NO Int J Mol Sci. 2020 Oct 28;21(21):8049. doi: 10.3390/ijms21218049. PMID: 33126763; PMCID: PMC7663623.Autores: Díaz-Flores L, Gutiérrez R, García MP, Gayoso S, Carrasco JL, Díaz-Flores L Jr, González-Gómez M, Madrid JF.
DS Repositorio institucional de la Universidad de La Laguna
RD 16-may-2024