RT info:eu-repo/semantics/article
T1 Genetic changes with prognostic value in histologically benign meningiomas
A1 Barbera, Sandra
A1 San-Miguel, Teresa
A1 Gil-Benso, Rosario
A1 Muñoz-Hidalgo, Lisandra
A1 Roldan, Pedro
A1 González-Darder, José
A1 Cerdá-Nicolás, Miguel J.
A1 López-Ginés, Concha
K1 Meningioma
K1 Recurrence
K1 Cytogenetics
K1 Chromosome 1p
K1 Chromosome 14
AB Meningiomas add up to 25% of intracranial tumors. Although the majority is considered histologically benign, the prediction of their potential aggressiveness is still unclear. We studied the histopathology and aberrations of chromosomes 1p, 14, and 22 by FISH (fluorescence in situ hybridization) in histologically benign meningiomas of 70 patients for the purpose of defining the prognostic value of these alterations in tumoral progression and the risk of recurrence. According to the WHO histopathological criteria, the study set comprised 53 benign, 11 atypical, and 6 anaplastic meningiomas. In benign meningiomas, 25% of the cases displayed a normal karyotype, isolated monosomy 22 (36%), monosomy 22 + 1p deletion (14%), 1p deletion (10%), monosomy 22 + 14q deletion (5%), monosomy 22 + 1p deletion + 14q deletion (5%), or other alterations (5%). Grade II meningiomas presented losses in chromosome 14 in most of the cases (67%), and Grade III meningiomas showed alterations in chromosome 14 in all patients. We observed an overall relapse rate of 31%: recurrence was observed in 19% of Grade I meningiomas, 64% of Grade II, and 83% of Grade III. 9 out of 10 recurrent cases revealed abnormalities in chromosomes 1 and 14, which was a notably higher incidence compared to the series of tumors without relapse. Thus, benign meningiomas with cytogenetic alterations in chromosomes 1p and 14 may be more closely related to atypical meningiomas than benign meningiomas without these alterations, especially in terms of recurrence risk.
SN 0722-5091
YR 2013
FD 2013
LK http://riull.ull.es/xmlui/handle/915/36175
UL http://riull.ull.es/xmlui/handle/915/36175
DS Repositorio institucional de la Universidad de La Laguna
RD 18-may-2024