RT info:eu-repo/semantics/article
T1 Molecular progression in unusual recurrent non-pediatric intracranial clear cell meningioma.
A1 Domingo-Arrué, B.
A1 Gil-Benso, Rosario
A1 Megías Vericat, Javier
A1 Navarro Cerveró, Lara
A1 San-Miguel, Teresa
A1 Muñoz-Hidalgo, Lisandra
A1 López Ginés, Concha
A1 Cerdá-Nicolás, Miguel J.
K1 Clear cell meningioma
K1 Recurrence
K1 Intracranial disease
K1 Non-pediatric disease
K1 Genetics
K1 NF2
K1 Tumour suppressor genes
K1 Molecular progression
AB We report a case of a recurrent clear cell meningioma (ccm) in the frontal lobe of the brain of a 67-year-old man. The patient developed three recurrences: at 3, 10, and 12 years after his initial surgery. Histopathology observations revealed a grade 2 ccm with positivity for vimentin and epithelial membrane antigen. Expression of E-cadherin was positive only in the primary tumour and in the first available recurrence. Fluorescence in situ hybridization analyses demonstrated 1p and 14q deletions within the last recurrence. Multiplex ligation-dependent probe amplification studies revealed a heterozygous partial NF2 gene deletion, which progressed to total loss in the last recurrence. The last recurrence showed homozygous deletions in CDKN2A and CDKN2B. The RASSF1 gene was hypermethylated during tumour evolution. In this report, we show the genetic alterations of a primary ccm and its recurrences to elucidate their relationships with the changes involved in the progression of this rare neoplasm.
SN 1718-7729
YR 2017
FD 2017
LK http://riull.ull.es/xmlui/handle/915/36188
UL http://riull.ull.es/xmlui/handle/915/36188
LA en
DS Repositorio institucional de la Universidad de La Laguna
RD 16-may-2024