RT info:eu-repo/semantics/article
T1 3,-Hydroxy-3,4,-dimethoxyflavone blocks tubulin polymerization and is a potent apoptotic inducer in human SK-MEL-1 melanoma cells
A1 García González, Celina Elena
A1 Estévez-Sarmiento, Francisco
A1 Said, Mercedes
A1 Brouard, Ignacio
A1 León, Francisco
A1 Quintana, José
A1 Estévez, Francisco
K1 Apoptosis
K1 Caspases
K1 Cytotoxicity
K1 Flavonoids
K1 Melanoma
AB Flavonoids are naturally occurring polyphenolic compounds and are among the most promising anticancer agents. A series of flavonols and their 3-methyl ether derivatives were synthesized and assessed for cytotoxicity. It was found that 3´-hydroxy-3,4´dimethoxyflavone (flavonoid 7a) displayed strong cytotoxicity against human SKMEL-1 melanoma cells and blocked tubulin polymerization, but had no significant cytotoxic effects against quiescent or proliferating human peripheral blood mononuclear cells. Our analyses showed that flavonoid 7a induces G2-M cell cycle arrest and apoptosis in melanoma cells which is associated with cytochrome c release and activation of both extrinsic and intrinsic apoptotic pathways of cell death.
SN 0968-0896
YR 2017
FD 2017
LK http://riull.ull.es/xmlui/handle/915/36261
UL http://riull.ull.es/xmlui/handle/915/36261
LA en
DS Repositorio institucional de la Universidad de La Laguna
RD 15-may-2024