RT info:eu-repo/semantics/article
T1 Evolving immunometabolic response to the early Leishmania infantum infection in the spleen of BALB/c mice described by gene expression profiling.
Palacios G, Diaz-Solano R, Valladares B, Dorta-Guerra R, Carmelo E.
Acta Trop. 2023 Nov;247:107005. doi: 10.1016/j.actatropica.2023.107005. Epub 2023 Aug 22.
PMID: 37619900
A1 Carmelo, Emma
A1 Palacios, G´énesis
A1 Díaz-Solano, Raquel
A1 Valladares Hernández, Basilio
A1 Dorta Guerra, Roberto
A2 Obstetricia y GinecologíaPediatría, Medicina Preventiva y Salud Pública, Toxicología y Medicina Legal y Forense y Parasitología
A2 Investigación en Parasitología
K1 Transcriptional changes
K1 Gene expression profile
K1 Over-represented pathways
K1 Leishmania infantum
K1 Mice spleen
K1 Visceral leishmaniasis
AB Transcriptional analysis is a useful approximation towards the identification of global changes in host-pathogen interaction, in order to elucidate tissue-specific immune responses that drive the immunopathology of the disease. For this purpose, expression of 223 genes involved in innate and adaptive immune response, lipid metabolism, prostaglandin synthesis, C-type lectin receptors and MAPK signaling pathway, among other processes, were analyzed during the early infection in spleens of BALB/c mice infected by Leishmania infantum. Our results highlight the activation of immune responses in spleen tissue as early as 1 day p.i., but a mixed pro-inflammatory and regulatory response at day 10 p.i., failing to induce an effective response towards control of Leishmania infection in the spleen. This ineffective response is coupled to downregulation of metabolic markers relevant for pathways related to icosanoid biosynthesis, adipocytokine signaling or HIF-1 signaling, among others. Interestingly, the over-representation of processes related to immune response, revealed Il21 as a potential early biomarker of L. infantum infection in the spleen. These results provide insights into the relationships between immune and metabolic responses at transcriptional level during the first days of infection in the L. infantum- BALB/c experimental model, revealing the deregulation of many important pathways and processes crucial for parasitic control in infected tissues.
YR 2023
FD 2023
LK http://riull.ull.es/xmlui/handle/915/37285
UL http://riull.ull.es/xmlui/handle/915/37285
LA en
NO Revista: Acta TropicaISSN: 1873-6254, 0001-706XAño de publicación: 2023Volumen: 247Tipo: Artículo
DS Repositorio institucional de la Universidad de La Laguna
RD 16-jun-2024